Oxidative Stress and the Neurovascular Unit
Carmela Rinaldi, Luigi Donato, Simona Alibrandi, Concetta Scimone, Rosalia D’Angelo, Antonina Sidoti
Abstract
The neurovascular unit (NVU) is a relatively recent concept that clearly describes the relationship between brain cells and their blood vessels. The components of the NVU, comprising different types of cells, are so interrelated and associated with each other that they are considered as a single functioning unit. For this reason, even slight disturbances in the NVU could severely affect brain homeostasis and health. In this review, we aim to describe the current state of knowledge concerning the role of oxidative stress on the neurovascular unit and the role of a single cell type in the NVU crosstalk.
Topics & Concepts
Neurovascular bundleOxidative stressUnit (ring theory)CrosstalkHomeostasisNeuroscienceMedicineCell biologyBiologyPathologyPsychologyInternal medicineEngineeringMathematics educationElectronic engineeringBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsAngiogenesis and VEGF in Cancer