Photochemical study of the highly used corticosteroids dexamethasone and prednisone. Effects of micellar confinement and cytotoxicity analysis of photoproducts
R. Daniel Cacciari, Eugenia Reynoso, Florencia Menis Candela, Carola Sabini, Hernán A. Montejano, M. Alicia Biasutti
Abstract
Photodegradation of dexamethasone (Dexa) and prednisone (Pred) occurs by a combination of ROS attack and unimolecular photodegradation reactions. The photoproducts obtained are more cytotoxic than the parent compounds.
Topics & Concepts
ChemistryDexamethasoneCytotoxicityPrednisonePhotochemistryBiochemistryInternal medicineIn vitroMedicinePhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsSkin Protection and Aging