Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway
Yan Mao, Feng Jiang, Xue-Jiao Xu, Lan‐Bo Zhou, Rui Jin, Lili Zhuang, Chenxia Juan, Guoping Zhou
Abstract
. In conclusion, IGF2BP1 was a potent pyroptosis inducer in septic AKI through targeting the MIF component of NLRP3 inflammasomes. Inhibiting IGF2BP1 could be an alternate pyroptosis-based treatment for septic AKI.
Topics & Concepts
PyroptosisMacrophage migration inhibitory factorChromatin immunoprecipitationDownregulation and upregulationTranscription factorInflammationBiologyE2F1Molecular biologyImmunologyGene expressionCytokineGenePromoterBiochemistryInflammasomeMacrophage Migration Inhibitory FactorRNA modifications and cancerCardiac Structural Anomalies and Repair