Catalytic in vivo protein knockdown by small-molecule PROTACs
Daniel P. Bondeson, Alina Mares, Ian E. Smith, Eunhwa Ko, Sébastien Campos, Afjal H. Miah, Katie E Mulholland, Natasha Routly, Dennis L. Buckley, Jeffrey L. Gustafson, Nico Zinn, Paola Grandi, Satoko Shimamura, Giovanna Bergamini, Maria Faelth-Savitski, Marcus Bantscheff, Carly S. Cox, Deborah A. Gordon, Ryan R. Willard, John J. Flanagan, Linda Casillas, Bartholomew J. Votta, Willem den Besten, Kristoffer Famm, Laurens Kruidenier, Paul S. Carter, John D. Harling, Ian Churcher, Craig M. Crews
Topics & Concepts
Gene knockdownUbiquitinUbiquitin ligaseSmall moleculeTarget proteinProtein degradationDrug discoveryRNA interferenceCell biologyIn vivoProteolysisChemistryBiologyComputational biologyBiochemistryGeneticsEnzymeRNAGeneApoptosisProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways