Design, synthesis and in vitro cytotoxic evaluation of β-carboline tethered quinoline-4-carboxamide conjugates as DNA-interactive Topo II inhibitors
Jay Prakash Soni, Priyanka Devi, Sowjanya Chemitikanti, Anamika Sharma, Chintha Venkata Dinesh Swamy, Regur Phanindranath, Manda Sathish, Narayana Nagesh, Chandraiah Godugu, Nagula Shankaraiah
Topics & Concepts
ChemistryCytotoxicityQuinolineMCF-7ApoptosisIn silicoIC50In vitroStereochemistryCell cultureDNACancer cellBiochemistryCancerGeneticsGeneBiologyHuman breastOrganic chemistrySynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsHIV/AIDS drug development and treatment