Case-control study in ALS using the National ALS Registry: lead and agricultural chemicals are potential risk factors
Hiroshi Mitsumoto, Diana C. Garofalo, Madison Gilmore, Leslie Andrews, Regina M. Santella, Howard Andrews, Martin McElhiney, Jennifer Murphy, Jeri W. Nieves, Judith G. Rabkin, Jonathan Hupf, D. Kevin Horton, Paul Mehta, Pam Factor‐Litvak
Abstract
: Findings reveal increased risk of ALS diagnosis among those with occupational exposure to lead and ACs and increased OS biomarkers among cases compared to controls. OS may be an important pathogenic mechanism in ALS.
Topics & Concepts
MedicineSocioeconomic statusPopulationCase-control studyDemographyInternal medicineEnvironmental healthSociologyPesticide Exposure and ToxicityAmyotrophic Lateral Sclerosis ResearchCarcinogens and Genotoxicity Assessment