Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering
Sanghwan Ko, Migyeong Jo, Sang Taek Jung
Topics & Concepts
AntibodyIn vivoInternalizationImmunoglobulin GIn vitroImmunologyHumanized mouseTherapeutic indexNeonatal Fc receptorIntracellularChemistryEndosomePharmacokineticsPotencyPharmacologyBiologyDrugImmune systemCell biologyReceptorBiochemistryBiotechnologyMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchProtein purification and stability