Fighting Cardiac Fibrosis with CAR T Cells
Scott L. Friedman
Abstract
Autologous chimeric antigen receptor T cells, which are engineered to bind and kill cells that express a specific antigen, are effective in the treatment of certain cancers. A recent study involving a mouse model shows that CAR T cells can be generated in vivo and may reduce fibrosis after myocardial injury.
Topics & Concepts
Chimeric antigen receptorMedicineFibrosisAntigenIn vivoCancer researchCardiac fibrosisMyocardial fibrosisImmunologyT cellPathologyImmune systemBiologyBiotechnologyCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsCRISPR and Genetic Engineering