Siderophore-Based Noninvasive Differentiation of Aspergillus fumigatus Colonization and Invasion in Pulmonary Aspergillosis
Dominika Luptáková, Rutuja H. Patil, Radim Dobiáš, David A. Stevens, Tomáš Pluháček, Andrea Palyzová, Marcela Káňová, Milan Navrátil, Zbyněk Vrba, Petr Hubáček, Vladimı́r Havlı́ček
Abstract
The importance of this research lies in the demonstration that siderophore analysis can distinguish between asymptomatic colonization and invasive pulmonary aspergillosis. We found clear associations between phases of fungal development, from conidial germination to the proliferative stage of invasive aspergillosis, and changes in secondary metabolite secretion.
Topics & Concepts
Aspergillus fumigatusGalactomannanMicrobiologyAspergillosisBiologyColonizationAspergillusInternal medicineImmunologyMedicineAntifungal resistance and susceptibilityPlant Pathogens and Fungal DiseasesFungal Biology and Applications