Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage
Jine Li, Erica Sparkenbaugh, Guowei Su, Fuming Zhang, Yongmei Xu, Ke Xia, Pen He, Sultan Nacak Baytaş, Shannon M. Pechauer, Anand Padmanabhan, Robert J. Linhardt, Rafał Pawliński, Jian Liu
Abstract
does not display anticoagulant activity nor react with heparin-induced thrombocytopenia antibodies isolated from patients. The successful synthesis of CS-E oligosaccharides provides structurally defined carbohydrates for advancing CS-E research and offers a potential therapeutic agent to treat life-threatening systemic inflammation.
Topics & Concepts
LipopolysaccharideChondroitin sulfateChemistryEnzymeHeparinBiochemistryGlucuronic acidPolysaccharideChondroitinBacteriaSulfationInflammationGlycosaminoglycanBiologyImmunologyGeneticsProteoglycans and glycosaminoglycans researchNeutrophil, Myeloperoxidase and Oxidative MechanismsProtease and Inhibitor Mechanisms