Immunomodulatory Response of Toll-like Receptor Ligand–Peptide Conjugates in Food Allergy
Jorge Losada Méndez, Francisca Palomares, Francisca Gómez, Pedro Ramírez‐López, Javier Ramos‐Soriano, Marı́a José Torres, Cristobalina Mayorga, Javier Rojo
Abstract
]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen-adjuvant systems in food allergy immunotherapy.