New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and <i>in silico</i> studies
Hazem Elkady, Alaa Elwan, Hesham A. El‐Mahdy, Ahmed S. Doghish, Ahmed Ismail, Mohammed S. Taghour, Eslam B. Elkaeed, Ibrahim H. Eissa, Mohammed A. Dahab, Hazem A. Mahdy, Mohamed M. Khalifa
Abstract
docking studies were also performed to get better insights into the possible binding mode of the target compounds with VEGFR-2 active sites.
Topics & Concepts
BenzoxazoleChemistryIn silicoCytotoxic T cellApoptosisCytotoxicityInducerCombinatorial chemistryCell cultureStereochemistryPharmacologyBiochemistryIn vitroBiologyOrganic chemistryGeneticsGeneAngiogenesis and VEGF in CancerHER2/EGFR in Cancer ResearchPI3K/AKT/mTOR signaling in cancer