Computational study and in vitro alpha-glucosidase inhibitory effects of medicinal plants from a Thai folk remedy
Komgrit Eawsakul, Pharkphoom Panichayupakaranant, Tassanee Ongtanasup, Sakan Warinhomhoun, Kunwadee Noonong, Kingkan Bunluepuech
Abstract
= 1.09 nM, 3 HBs and 4 HIs). These compounds bind with high affinity to different binding pockets, leading to additive effects. Moreover, the pharmacokinetics of six of these seven compounds (except ergosterol peroxide) showed poor absorption in the gastrointestinal tract, which would allow for competitive binding to AG in the small intestine. These results indicate that the development of these 6 compounds into oral antidiabetic agents is promising.
Topics & Concepts
IC50Traditional medicineAlpha-glucosidaseChemistryPharmacologyMedicineIn vitroBiochemistryEnzymeAndrographolide Research and ApplicationsNatural Antidiabetic Agents StudiesPhytochemicals and Medicinal Plants