A carbon dot-doped Cu-MOF-based smart nanoplatform for enhanced immune checkpoint blockade therapy and synergistic multimodal cancer therapy
Zhongping Su, Haiying Xu, Ying Zhang, Huanli Zhang, Hui Zhang, Yujun Bao, Xiaodan Wu, Rui Yan, Guanghui Tan, Zhiqiang Wang, Yingxue Jin
Abstract
and amplifies reactive oxygen species (ROS) levels in cells, thus leading to enhanced PDT and chemodynamic therapy (CDT) effect. Moreover, programmed cell death-ligand 1 antibody (anti-PD-L1) is used together to enable combination therapy, as Cu-MOF@RCD can significantly enhance host immunogenicity. In summary, the combination of Cu-MOF@RCD with anti-PD-L1 antibody exerts a synergistic PDT/PTT/CDT/DG/ICB therapy and can be used to eradicate the primary tumors and inhibit the growth of untreated distant tumors and tumor metastasis.
Topics & Concepts
BlockadeImmune checkpointCancer therapyMaterials scienceMultimodal therapyImmune systemNanotechnologyCancer researchCancerMedicineImmunologyInternal medicineReceptorNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisCarbon and Quantum Dots Applications