Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis
Mick J M van Eijs, J. J. M. Ter Linde, Matthijs J.D. Baars, Mojtaba Amini, Miangela M. Laclé, Eelco C. Brand, Eveline M. Delemarre, Julia Drylewicz, Stefan Nierkens, Rik J. Verheijden, Bas Oldenburg, Yvonne Vercoulen, Karijn P.M. Suijkerbuijk, Femke van Wijk
Abstract
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Topics & Concepts
ColitisImmune systemUlcerative colitisCytotoxic T cellCD8Lamina propriaImmunologyInflammatory bowel diseaseGranzyme BCancer researchMedicineBiologyPathologyDiseaseIn vitroEpitheliumBiochemistrySingle-cell and spatial transcriptomicsT-cell and B-cell ImmunologyImmune cells in cancer