Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis
Zhen Zhang, Peichang Cao, Mengyuan Fang, Tingfeng Zou, Jihong Han, Yajun Duan, Hua‐Jian Xu, Xiaoxiao Yang, Qing-Shan Li
Topics & Concepts
ChemistryThiazoleSepsisPharmacologyNitric oxidePharmacophoreNitric oxide synthaseTumor necrosis factor alphaInflammationAnti-inflammatoryStructure–activity relationshipStereochemistryBiochemistryEnzymeIn vitroImmunologyMedicineOrganic chemistryInflammation biomarkers and pathwaysSynthesis of heterocyclic compoundsBioactive Compounds and Antitumor Agents