Simultaneous extraction and analysis of clozapine and lorazepam from human plasma using dual solvent-stir bar microextraction with different acceptor phases followed by high-performance liquid chromatography ultra-violet detection
Mahsa Sheikh, Mohammad Reza Hadjmohammadi, M. Fatemi
Abstract
= 0.9993). Extraction recovery and the enrichment factor for CLZ were 95.4% and 343 and for LRP they were 74.3% and 263, respectively. Finally, the method developed was successfully applied for the simultaneous determination of CLZ and LRP in human plasma samples.
Topics & Concepts
ChromatographyLorazepamHigh-performance liquid chromatographyExtraction (chemistry)SolventChemistryHuman plasmaAcceptorBar (unit)Organic chemistryAnesthesiaMedicineMeteorologyCondensed matter physicsPhysicsAnalytical chemistry methods developmentAnalytical Chemistry and ChromatographyForensic Toxicology and Drug Analysis