Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor
Daniel Rodrigues, Mirele R. Machado, Juliano Alves, Thais Fernanda de Campos Fraga‐Silva, Ronaldo B. Martins, Ligia C.B. Campos, Daniely Franco Francisco, Ariel E.S. Couto, Vânia Luiza Deperon Bonato, Eurico Arruda, Christiane Becari, Maria Auxiliadora‐Martins, Paulo Louzada‐Júnior, Rafael M. Costa, Rita C. Tostes
Abstract
We demonstrate that endothelial cell dysfunction in SARS-CoV-2-infected individuals is linked to decreased activity of the major antioxidant system regulator, the Nrf2 transcription factor. We provide evidence that this phenomenon relies on IL-6, an important cytokine involved in the pathophysiology of COVID-19. Our data support the view that Nrf2 activation is a potential therapeutical strategy to prevent oxidative stress and vascular inflammation in severe cases of COVID-19.