Review on anticancer activity of flavonoid derivatives: Recent developments and future perspectives
Mani Rajasekar, Palanisamy Bhuvanesh, Pramod Varada, Masilamani Selvam
Abstract
A group of secondary plant metabolites known as flavonoids, which are polyphenolic chemicals, have a variety of pharmacological properties, including anti-cancer properties. By modifying various enzymes and receptors in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis, and reversal of multi-drug resistance, they have been reported to interfere with the beginning, promoting, and progression of cancer. Flavonoids are being researched for their possible using cancer treatments due to their numerous molecular modes of action. By offering fresh perspectives on the variables, regulation, and molecular mechanisms as well as their major protein interactions, the current review highlights the therapeutic promise of nano-encapsulation flavonoids and their synthetic analogs as anti-cancer medicines.