Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats
Asmaa Magdy Zaazaa, Bosy A. Abd El-Motelp, Naglaa A. Ali, Ahmed M. Youssef, Mohamed Sayed, Safaa Mohamed
Abstract
ameliorating the oxidative stress and inflammatory markers. Moreover, Histopathological studies had shown that great development in the brain of Cad rats treated with MSCs-Exo and CuSNPs. In conclusion, this study offers an overview of innovative stem cell therapy techniques and how to integrate them with nanotechnology to boost therapeutic performance.
Topics & Concepts
Mesenchymal stem cellOxidative stressPharmacologyBrain-derived neurotrophic factorNeurotrophic factorsMicrovesiclesNerve growth factorCadmium chlorideStem-cell therapyMedicineTumor necrosis factor alphaAcetylcholinesteraseStem cellNeurotrophinChemistryInternal medicineEndocrinologyPathologyCadmiumBiologyBiochemistryReceptorCell biologyGeneEnzymemicroRNAOrganic chemistryHeavy Metal Exposure and ToxicityMesenchymal stem cell researchNeuroinflammation and Neurodegeneration Mechanisms