How repertoire data are changing antibody science
Claire Marks, Charlotte M. Deane
Abstract
antigen-inexperienced) and that after immunization. This wealth of data has created opportunities to learn more about our immune system. In this review, we discuss the many ways in which BCR repertoire data have been or could be exploited. We highlight its utility for providing insights into how the naive immune repertoire is generated and how it responds to antigens. We also consider how structural information can be used to enhance these data and may lead to more accurate depictions of the sequence space and to applications in the discovery of new therapeutics.
Topics & Concepts
RepertoireSomatic hypermutationAntibody RepertoireAntigenBiologyAntibodyComputational biologyImmune systemImmunologybreakpoint cluster regionInnate immune systemB cellGeneticsReceptorPhysicsAcousticsMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunologyvaccines and immunoinformatics approaches