New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Amin Jesmani, Nafise Birang, Korosh Morshedi, Hashem Khanbabaei, Haroon Khan, Ashkan Piranviseh, Majid Nejati, Michael Aschner, Hamed Mirzaei
Abstract
Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.