Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Karen Sargsyan, Chien-Chu Lin, Ting Chen, Cédric Grauffel, Yi‐Ping Phoebe Chen, Wei‐Zen Yang, Hanna S. Yuan, Carmay Lim
Abstract
protease. We propose combining disulfiram/ebselen with broad-spectrum antivirals/drugs to target different conserved domains acting at various stages of the virus life cycle to synergistically inhibit SARS-CoV-2 replication and reduce the emergence of drug resistance.
Topics & Concepts
DruggabilitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyConserved sequenceCoronavirus disease 2019 (COVID-19)BiologyGeneticsEvolutionary biologyBioinformaticsMedicineBase sequenceGeneInfectious disease (medical specialty)Internal medicineDiseaseClick Chemistry and ApplicationsSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods