Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors
Guoqing Lu, Wenxing Nie, Meixiu Xin, Yingfen Meng, Jiayi Gu, Hui Miao, Xinyi Cheng, A.S.C. Chan, Yong Zou
Topics & Concepts
Poly ADP ribose polymeraseBenzamideChemistryPolymeraseDNA repairHeLaEnzymeBiochemistryDocking (animal)Cell cycle checkpointApoptosisCancer cellCell biologyCell cycleDNAStereochemistryCellBiologyCancerNursingMedicineGeneticsPARP inhibition in cancer therapyCancer therapeutics and mechanismsDNA Repair Mechanisms