PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis
Yongqiang Hou, Wei Liu, Xianfu Yi, Yang Yang, Dongxue Su, Wei Huang, Hefen Yu, Xu Teng, Ying Yang, Feng Wei, Tao Zhang, Jie Gao, Kai Zhang, Rongfang Qiu, Yan Wang
Abstract
deletion not only induces growth retardation and mammary ductal outgrowth delay but also inhibits tumorigenesis in vivo. Our data indicate that PHF20L1 promotes tumorigenesis, supporting the pursuit of PHF20L1 as a target for cancer therapy.
Topics & Concepts
CarcinogenesisRepressorBreast cancerComputational biologyChemistryBiologyCancer researchGeneticsCancerTranscription factorGeneEpigenetics and DNA MethylationRNA modifications and cancerGenomics and Chromatin Dynamics