Evaluation of Two Commercial Broth Microdilution Methods Using Different Interpretive Criteria for the Detection of Molecular Mechanisms of Acquired Azole and Echinocandin Resistance in Four Common <i>Candida</i> Species
Ha Jin Lim, Jong Hee Shin, Mi‐Na Kim, Dongeun Yong, Seung A. Byun, Min Ji Choi, Seung Yeob Lee, Eun Jeong Won, Seung‐Jung Kee, Soo Hyun Kim, Myung‐Geun Shin
Abstract
The abilities of the new Vitek 2 AST-YS08 (YS08) and Sensititre YeastOne (SYO) systems to detect the resistances of Candida isolates to azoles and echinocandins were evaluated. In total, 292 isolates, including 28 Candida albicans (6 Erg11 and 2 Fks mutants), 57 Candida parapsilosis (26 Erg11 mutants), 24 Candida tropicalis (10 Erg11 and 1 Fks mutants), and 183 Candida glabrata (39 Pdr1 and 13 Fks mutants) isolates, were tested.
Topics & Concepts
EchinocandinsCandida glabrataEchinocandinCandida parapsilosisCandida tropicalisCandida albicansMicrobiologyBiologyBroth microdilutionAzoleMutantAnidulafunginMicafunginFluconazoleAntifungalMinimum inhibitory concentrationBiochemistryAntimicrobialCaspofunginGeneAntifungal resistance and susceptibilitySynthesis and Biological EvaluationAntibiotics Pharmacokinetics and Efficacy