Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue
Rémi Martinent, Salman Tawffik, Javier López‐Andarias, Dimitri Moreau, Quentin Laurent, Stefan Matile
Abstract
, constitutional isomers. Reviving a classic in peptide chemistry, this templated assembly of β quartets promises to expand streptavidin biotechnology in new directions, while the discovery of general cytosolic delivery in deep tissue as an intrinsic advantage further enhances the significance and usefulness of thiol-mediated uptake.
Topics & Concepts
CytosolChemistryStreptavidinBiophysicsTranscytosisPeptideSupramolecular chemistryThiolDithiolaneNanotechnologyBiochemistryCombinatorial chemistryCellEndocytosisStereochemistryBiotinBiologyEnzymeMaterials scienceCrystallographyCrystal structureRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials