Investigations of potent biocompatible metal-organic framework for efficient encapsulation and delivery of Gemcitabine: biodistribution, pharmacokinetic and cytotoxicity study
Preeti Kush, Manjot Kaur, Monika Sharma, Jitender Madan, Parveen Kumar, Akash Deep, Ki‐Hyun Kim
Abstract
(rigid), MIL-88A, and MIL-53 (flexible). All these MOFs have different topologies, connectivity, and chemical composition. MIL-53 was identified as a promising carrier for GEM delivery, with enhanced encapsulation and progressive release in relation to other candidates. The release of GEM from MIL-53 followed zero order kinetics, leading to an effective plasma concentration within the therapeutic range. Furthermore, in- vitro cytotoxicity study by using pancreatic cancer cell lines (MIAPaCa-2 and PANC1) stipulated that GEM loaded in MIL-53 (MIL53-GEM) had an increased cytotoxic effect relative to native GEM. Additionally, the slow release of GEM in a controlled manner could protect the drug from enzymatic degradation to increase its efficacy, half-life, and bioavailability without toxicity to organs as evidenced by in-vivo studies. This study demonstrates the potential of MIL53-GEM in upgrading the clinical outcome of GEM-based chemotherapy against cancer.