Litcius/Paper detail

Application of LAPM and ABM methods to a fractional SCIR model of pneumonia diseases

Muflih Alhazmi, Safa M. Mirgani, Abdullah Alahmari„, Sayed Saber

2025AIMS Mathematics6 citationsDOIOpen Access PDF

Abstract

We develop a fractional SCIR (susceptible-carrier-infected-recovered) model for pneumococcal pneumonia using Caputo derivatives of order $ 0 < \varrho \leq 1 $ to capture memory effects from long carriage, waning immunity, and reinfection. The force of infection explicitly accounts for carriers' transmissibility. Using a next-generation approach, we derive the basic reproduction number $ \mathscr{R}_0 $ and prove the global asymptotic stability of the disease-free equilibrium when $ \mathscr{R}_0 < 1 $ and of the endemic equilibrium when $ \mathscr{R}_0 > 1 $ via Lyapunov functionals and a fractional LaSalle principle. Numerically, we combine the Laplace-Adomian-Padé method (LAPM) with a fractional Adams-Bashforth-Moulton scheme (ABM) to capture memory-driven transients. A sensitivity analysis identifies transmission intensity and routing into carriage as the dominant epidemic drivers, while treatment and mortality exert mitigating effects. A control extension yields a closed-form, control-adjusted $ \mathscr{R}_0 $; a minimal vaccination threshold; and an optimal control problem solved numerically. Finally, we outline a calibration workflow linking the model-predicted incidence to surveillance data, permitting a statistical estimation of the fractional order. Altogether, incorporating carriers and fractional memory modifies the thresholds and persistence conditions, producing dynamics that are more consistent with pneumococcal epidemiology.

Topics & Concepts

MathematicsBasic reproduction numberStability (learning theory)MedicineCarriagePneumoniaExponential stabilityExtension (predicate logic)Applied mathematicsTransmission (telecommunications)Lyapunov functionMathematical optimizationComplement (music)VaccinationEpidemic modelIncidence (geometry)Fractional calculusStability theoryPneumococcal pneumoniaIntensive care medicineEconometricsSensitivity (control systems)Order (exchange)Lyapunov stabilityLong memoryControl theory (sociology)Term (time)Computer scienceVaccine efficacyFractional Differential Equations SolutionsCOVID-19 epidemiological studiesMathematical and Theoretical Epidemiology and Ecology Models