Microfluidic synthesis of hemin@ZIF-8 nanozyme with applications in cellular reactive oxygen species detection and anticancer drug screening
Yanping Wang, Shujun Feng, Xuyuan Wang, Chungui Tao, Yuta Liu, Yanyi Wang, Yanfeng Gao, Jinsong Zhao, Yujun Song
Abstract
secreted by viable cells with a detection threshold of approximately 10 cells per mL. By leveraging this method, we achieved successful detection of cancer cells and effective screening of anticancer drugs that induce oxidative stress injury in cancer cells. This innovative microfluidic strategy offers a new avenue for synthesizing functional nanocomposites to facilitate the development of next-generation diagnostic tools for early disease detection and personalized medicine.
Topics & Concepts
BioanalysisHeminZeolitic imidazolate frameworkBiomoleculeNanotechnologyChemistryReactive oxygen speciesMicrofluidicsImidazolateDrug deliveryDrugBiocompatible materialCombinatorial chemistryMaterials scienceMetal-organic frameworkBiochemistryPharmacologyBiologyBiomedical engineeringMedicineOrganic chemistryHemeAdsorptionEnzymeAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection