Mechanism of pH influence on aptamer binding with Cd<sup>2+</sup> revealed by molecular dynamics simulation
Hongen Yuan, Xiuxiu Wu, Xingfa Ren, Bin Xue, Wenjie Qiu, Dinghui Nong, Tao Yang, Fei Xu
Abstract
pH decrease changes the interbase hydrogen bonds and negative charge of the aptamer, destroying its affinity for Cd 2+ .
Topics & Concepts
ChemistryMolecular dynamicsMechanism (biology)AptamerDynamics (music)BiophysicsComputational chemistryMolecular biologyEpistemologyPhysicsBiologyAcousticsPhilosophyAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms