Litcius/Paper detail

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas, Nicholas Luke Cowie, Alejandro Gómez Toledo, Soo Min Noh, Karen Julie la Cour Karottki, Marianne Decker, Johnny Arnsdorf, Jose Manuel Camacho-Zaragoza, Stefan Kol, Sanne Schoffelen, Nuša Pristovšek, Anders Holmgaard Hansen, Antonio Alarcón Miguez, Sara Petersen Bjørn, Karen Kathrine Brøndum, Elham Maria Javidi, Kristian Jensen, Laura Stangl, Emanuel Kreidl, Thomas Beuchert Kallehauge, Daniel Ley, P Ménard, Helle Munck Petersen, Zulfiya Sukhova, Anton Bauer, Emilio Casanova, Niall Barron, Johan Malmström, Lars K. Nielsen, Gyun Min Lee, Helene Faustrup Kildegaard, Björn G. Voldborg, Nathan E. Lewis

2025Nature Metabolism19 citationsDOIOpen Access PDF

Topics & Concepts

Warburg effectLactate dehydrogenaseChinese hamster ovary cellLactate dehydrogenase ABiologyCell biologyBiochemistryCell growthDihydroxyacetoneCell cultureLactic acidGlycolysisMetabolismChemistryGlycerolEnzymeReceptorGeneticsBacteriaViral Infectious Diseases and Gene Expression in InsectsMicrobial Metabolic Engineering and BioproductionCRISPR and Genetic Engineering