An Integrated HOCl-Producing E-Scaffold Is Active against Monomicrobial and Polymicrobial Biofilms
Laure Flurin, Yash S. Raval, Abdelrhman Mohamed, Kerryl E. Greenwood‐Quaintance, Edison Cano Cevallos, Haluk Beyenal, Robin Patel
Abstract
Oxidizing agents like hypochlorous acid (HOCl) have antimicrobial activity. We developed an integrated electrochemical scaffold, or e-scaffold, that delivers a continuous low dose of HOCl aimed at targeting microbial biofilms without exceeding concentrations toxic to humans as a prototype of a device being developed to treat wound infections in humans.
Topics & Concepts
BiofilmHypochlorous acidChlorineMicrobiologyBacteriaOxidizing agentChemistryAntimicrobialIn vitroMicroorganismBiologyBiochemistryOrganic chemistryGeneticsBacterial biofilms and quorum sensingLegionella and Acanthamoeba researchNeutrophil, Myeloperoxidase and Oxidative Mechanisms