Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia
Abrey J. Yeo, Kok Leong Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst J. Wolvetang, Robert G. Parton, Adam Brown, Michael B. Kastan, David Coman, Martin F. Lavin
Abstract
homeostasis, as well as an abnormality in mitochondrial fusion defective in response to nutrient stress, can account for at least part of the mitochondrial dysfunction observed in A-T cells.
Topics & Concepts
Endoplasmic reticulumAtaxia-telangiectasiaSTIM1MitochondrionCell biologyChemistryNeuroscienceBiochemistryBiologyDNADNA damageDNA Repair MechanismsMitochondrial Function and PathologyCarcinogens and Genotoxicity Assessment