Epigenetic Aberrations in Multiple Myeloma
Cinzia Caprio, Antonio Sacco, Viviana Giustini, Aldo M. Roccaro
Abstract
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by proliferation of clonal plasma cells within the bone marrow. Several advances in defining key processes responsible for MM pathogenesis and disease progression have been made; and dysregulation of epigenetics, including DNA methylation and histone modification, has emerged as a crucial regulator of MM pathogenesis. In the present review article, we will focus on the role of epigenetic modifications within the specific context of MM.
Topics & Concepts
EpigeneticsPlasma cell dyscrasiaMultiple myelomaContext (archaeology)PathogenesisHistoneDNA methylationPlasma cellBiologyCancer researchBone marrowMedicineImmunologyGeneticsDNAGeneGene expressionImmunoglobulin light chainAntibodyPaleontologyMultiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors