Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity
Yousuke Yamada, Hajime Takashima, Lee Walmsley, Fumihito Ushiyama, Yohei Matsuda, Harumi Kanazawa, Toru Yamaguchi-Sasaki, Nozomi Tanaka-Yamamoto, Junya Yamagishi, Risa Kurimoto-Tsuruta, Yuya Ogata, Norikazu Ohtake, Hayley C. Angove, Lisa Baker, Richard Harris, Alba T. Macias, Alan Robertson, A.E. Surgenor, Hayato Watanabe, Koichiro Nakano, Masashi Mima, Kunihiko Iwamoto, Atsushi Okada, Iichiro Takata, Kosuke Hitaka, Akihiro Tanaka, Kiyoko Fujita, Hiroyuki Sugiyama, Roderick E. Hubbard
Abstract
, which is little affected by the presence of albumin.
Topics & Concepts
ChemistryMoietyAntibacterial activityImidazoleStereochemistryChelationEnzymeBiochemistryZincCombinatorial chemistryBacteriaOrganic chemistryBiologyGeneticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyCarbohydrate Chemistry and Synthesis