Formicins, <i>N</i>-Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium
Young Eun Du, Woong Sub Byun, Seok Beom Lee, Sunghoon Hwang, Yern‐Hyerk Shin, Bora Shin, Yong-Joon Jang, Suckchang Hong, Jongheon Shin, Sang Kook Lee, Dong‐Chan Oh
Abstract
Formicins A–C (1–3) were discovered from Streptomyces sp. associated with wood ants. The structures of 1 and 2 were elucidated as indenone thioesters bearing N-acetylcysteamine based on spectroscopic analysis. The configurations of 1–3 were determined by the analysis of ROESY correlations, the phenylglycine methyl ester method, and chemical derivatization from 3 to 2. Formicin A inhibited the growth of human triple-negative breast cancer cells by regulating the liver kinase B1-mediated AMPK signaling pathway.
Topics & Concepts
ChemistryBacteriaANTDerivatizationStereochemistryBiochemistryOrganic chemistryBiologyEcologyGeneticsHigh-performance liquid chromatographyMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsAntimicrobial Peptides and Activities