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Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex

Ana Uzquiano, Amanda J. Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason D. Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z. Levin, Paola Arlotta

2022Cell233 citationsDOIOpen Access PDF

Topics & Concepts

OrganoidBiologyCorticogenesisHuman brainNeuroscienceCell fate determinationTranscriptomeCell typeCellular differentiationEpigeneticsComputational biologyInduced pluripotent stem cellProgenitor cellCellCell biologyStem cellGeneticsGeneEmbryonic stem cellTranscription factorGene expressionSingle-cell and spatial transcriptomicsRNA Research and SplicingPluripotent Stem Cells Research
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex | Litcius