Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1
Yajun Liu, Meifang Wang, Derek Wang, William P. Fay, Ronald J. Korthuis, Grzegorz Sowa
Abstract
The role of caveolin-2 in regulating ischemia/reperfusion (I/R) tissue injury and the mechanisms underlying its effects are unknown. This study uses caveolin-2-deficient mouse and small intestinal I/R injury models to examine the role of caveolin-2 in the leukocyte-dependent reperfusion injury. We demonstrate for the first time that caveolin-2 plays a protective role from the I/R-induced leukocyte-dependent reperfusion injury by reducing PAI-1 protein levels in intestinal tissue and leukocyte-endothelial adhesive interactions in postcapillary venules.
Topics & Concepts
Caveolin 1Reperfusion injuryIschemiaLeukocyte TraffickingCaveolinInflammationPathologyMedicineBiologyImmunologyCell biologyCaveolaeInternal medicineSignal transductionChemokineCaveolin-1 and cellular processesIon channel regulation and functionCardiac Ischemia and Reperfusion