TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer
Hye Sook Han, Seongju Jeong, Hyunglae Kim, Hyung‐Don Kim, A.Reum Kim, Minsuk Kwon, Su‐Hyung Park, Chang Gok Woo, Hee Kyung Kim, Ki Hyeong Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Wun‐Jae Kim, Seok Joong Yun, Eui‐Cheol Shin
Topics & Concepts
TIGITImmunotherapyCD8Tumor microenvironmentBlockadeTumor-infiltrating lymphocytesImmune checkpointMedicineCancer researchCytotoxic T cellBladder cancerImmunologyCancerImmune systemInternal medicineOncologyReceptorBiologyIn vitroBiochemistryCancer Immunotherapy and BiomarkersBladder and Urothelial Cancer TreatmentsImmune Cell Function and Interaction