A trip of peptides to the brain
Toshiro Matsui, Atsuko Yoshino, Mitsuru Tanaka
Abstract
Abstract Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension, and hypercholesterolemia, etc. Although there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human, limited studies on bioavailability, in particular, beyond the blood-brain barrier (BBB) of candidates in hydrolysate may prevent their extensive physiological studies. Thus, this review discusses the updated studies on BBB transport of peptides showing improved cognitive decline. Furthermore, their accumulation in the brain cerebral parenchyma is also introduced. Graphical abstract
Topics & Concepts
HydrolysateBlood–brain barrierTripeptideBioavailabilityMedicineHuman brainPharmacologyPeptideNeurosciencePsychologyChemistryInternal medicineCentral nervous systemBiochemistryHydrolysisBiochemical effects in animalsAmino Acid Enzymes and MetabolismProtein Hydrolysis and Bioactive Peptides