m4C DNA methylation regulates biosynthesis of daptomycin in Streptomyces roseosporus L30
Jiao-Le Fang, Wen‐Li Gao, Weifeng Xu, Zhong-Yuan Lyu, Lie Ma, Shuai Luo, Xin-Ai Chen, Xu‐Ming Mao, Yong‐Quan Li
Abstract
L30 further revealed its role in enhancing daptomycin production. In summary, we characterized a m4C methyltransferase, revealed the function of m4C in secondary metabolism regulation and biosynthesis of red pigment, and mapped a series of novel regulators for daptomycin biosynthesis dominated by m4C methylation. Our research further indicated that m4C DNA methylation may contribute to a metabolic switch from primary to secondary metabolism in
Topics & Concepts
EpigeneticsDaptomycinSecondary metabolismMethyltransferaseBiologyDNA methylationStreptomycesMethylationDNA methyltransferaseRegulatorGeneBiosynthesisGeneticsGene expressionBacteriaStaphylococcus aureusVancomycinMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesRNA modifications and cancer