Role of adherent invasive <i>Escherichia coli</i> in pathogenesis of inflammatory bowel disease
Lie Zheng, Sheng-Lei Duan, Yan-Cheng Dai, Shi-Cheng Wu
Abstract
(AIEC) may contribute to a further understanding of IBD pathogenesis. This review explores the relationship between AIEC and the intestinal immune system, discusses the prevalence and relevance of AIEC in Crohn's disease and ulcerative colitis patients, and describes the relationship between AIEC and the disease site, activity, and postoperative recurrence. Finally, we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa, including the use of phage therapy, antibiotics, and anti-adhesion molecules. These strategies may open up new avenues for the prevention and treatment of IBD in the future.
Topics & Concepts
PathogenesisInflammatory bowel diseaseUlcerative colitisMedicineDiseaseImmunologyImmune systemCrohn's diseaseMicrobiologyIntestinal mucosaEscherichia coliAntibioticsBiologyPathologyInternal medicineGeneBiochemistryEscherichia coli research studiesGut microbiota and healthClostridium difficile and Clostridium perfringens research