Ultrasound-triggered prodrug activation <i>via</i> sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold
Xuancheng Fu, Bowen Xu, H.D. Sarath Liyanage, Cijun Zhang, Warren F Kincaid, Adrian Ford, Luke G. Westbrook, Seth D. Brown, Tatum DeMarco, James L. Hougland, John M. Franck, Xiaoran Hu
Abstract
. Remarkably, this sonochemical activation was successfully achieved through 2 cm of chicken breast, highlighting the deep-penetrating capability of our approach. Extending this strategy, we developed ProR848, a sono-activable prodrug of the Toll-like receptors (TLR) agonist R848, enabling remotely triggered, on-demand immune cell activation. Collectively, our results establish a novel and versatile sonochemical cleavage platform for ultrasound-targeted prodrug activation, offering significant potential for applications including controlled therapeutic release and responsive biomaterials.