Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis
Nikolay Popgeorgiev, D Jaison, Lea Jabbour, Suresh Banjara, Trang Thi Minh Nguyen, Aida Akhavan-E-Sabet, Rudy Gadet, Nikola Ralchev, Stéphen Manon, Mark G. Hinds, Hans‐Jürgen Osigus, Bernd Schierwater, Patrick O. Humbert, Ruth Rimokh, Germain Gillet, Marc Kvansakul
Abstract
to mammals. Finally, we demonstrate that both trBax and trBak BH3 peptides bind selectively to human Bcl-2 homologs to sensitize cancer cells to chemotherapy treatment.
Topics & Concepts
Bcl-2 familyApoptosisBiologyMitochondrionCell biologyProtein familyConserved sequenceGeneticsGeneProgrammed cell deathPeptide sequenceCell death mechanisms and regulationRNA Interference and Gene DeliveryMitochondrial Function and Pathology