Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular risk factors (data from Russian epidemiological studies)
О. М. Драпкина, S. E. Evstifeeva, S. А. Shalnova, В. А. Куценко, Yu. А. Balanova, А. Э. Имаева, А. В. Капустина, M. B. Kotova, С. А. Максимов, Г. А. Муромцева, O. А. Litinskaya, M. S. Pokrovskaya, E. M. Filichkina, А. G. Soplenkova, Л. И. Гоманова, Yu. V. Doludin, И. А. Ефимова, A. L. Borisova, N. S. Karamnova, O. B. Shvabskaya, И. А. Викторова, N. N. Prishchepa, A. N. Redko, S. S. Yаkushin, Т. В. Репкина, T. O. Gonoshilova, Alexander V. Kudryavtsev, Н. И. Белова, Л. Л. Шагров, М. А. Самотруева, A. L. Yasenyavskaya, Е. Н. Чернышева, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, Е. З. Урбанова, N. Yu. Borovkova, V. K. Kurashin, А. С. Токарева, Yu. I. Ragino, Г. И. Симонова, А. Д. Худякова, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovieva, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, И. В. Танцырева, И. Н. Барышникова, М. Г. Атаев, M. O. Radzhabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, И. А. Хакуашева, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, А. М. Никитина, Yu. E. Spiridonova, Н. В. Саввина, Е. А. Наумова, V. S. Yudin, Anton А. Keskinov, Д. А. Каштанова, S. M. Yudin, А. V. Kontsevaya
Abstract
Aim. To study the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with cardiovascular risk factors (RFs). Material and methods. The database from the ESSE-RF2 and ESSE-RF3 epidemiological studies was used, including data from surveys of population aged 35-64 years in 18 Russian regions (n=21204). To assess the prevalence of NAFLD, the fatty liver index (FLI) was used. Statistical analysis was performed using the statistical programming language and the R environment (version 3.6.1) with open-source code. The significance level for all tested hypotheses was p≤0,05. Results. Standardized prevalence rates of FLI ≥60 in the ESSE-RF3 study are slightly higher than in the ESSE-RF2 study (39,2% vs 42,3%, respectively). Multivariate analysis adjusted for sex, age, region, settlement type, and education showed significant associations of FLI ≥60 with hypertension, type 2 diabetes, hyperuricemia, lipid metabolism disorders, elevated high-sensitivity C-reactive protein levels, and cerebrovascular accident in men and women. Conclusion. Multivariate analysis confirmed the closest association of NAFLD with hypertension, type 2 diabetes mellitus, metabolic disorders, nonspecific inflammation, dyslipidemia, and cerebrovascular accident in men and women.