Machine learning-guided multi-site combinatorial mutagenesis enhances the thermostability of pectin lyase
Zhihui Zhang, Zhixuan Li, Manli Yang, Fengguang Zhao, Shuangyan Han
Topics & Concepts
ThermostabilityMutantDirected evolutionProtein engineeringSequence spaceCombinatorial methodMutagenesisComputational biologyChemistryBiochemistryEnzymeCombinatorial chemistryBiologyMathematicsCombinatoricsGeneBanach spacePure mathematicsBiochemical and Structural CharacterizationTransgenic Plants and ApplicationsGlycosylation and Glycoproteins Research