Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection
Melissa D. Pinto, Natalie Lambert, Charles A. Downs, Heather L. Abrahim, Thomas Hughes, Amir M. Rahmani, Candace W. Burton, Rana Chakraborty
Abstract
Postacute sequelae of SARS-CoV2 (PASC) infection is an emerging global health crisis, variably affecting millions worldwide. PASC has no established treatment. We describe 2 cases of PASC in response to opportune administration of over-the-counter antihistamines, with significant improvement in symptoms and ability to perform activities of daily living. Future studies are warranted to understand the potential role of histamine in the pathogenesis of PASC and explore the clinical benefits of antihistamines in the treatment of PASC.
Topics & Concepts
MedicineIntensive care medicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)PathologyDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19COVID-19 and Mental HealthCOVID-19 Clinical Research Studies