Lipid metabolism in MASLD and MASH: From mechanism to the clinic
Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Abstract
lipogenesis and excess fatty acid transport to the liver (due to increased lipolysis, adipose tissue insulin resistance, as well as excess dietary fatty acid intake, in particular of saturated fatty acids). Not only triglycerides but also other lipids are secreted by the liver and are associated with a worse histological profile in MASH, as shown by lipidomics. Herein, we review the role of lipid metabolism in MASLD/MASH and discuss the impact of weight loss (diet, bariatric surgery, GLP-1RAs) or other pharmacological treatments (PPAR or THRβ agonists) on hepatic lipid metabolism, lipidomics, and the resolution of MASH.
Topics & Concepts
LipogenesisLipolysisLipidomicsLipid metabolismInsulin resistanceEndocrinologyAdipose tissueInternal medicineTriglycerideFatty acid synthesisFatty liverSteatosisFatty acidMetabolismChemistryBiologyBiochemistryInsulinMedicineCholesterolDiseaseLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis