NINJ1: Bridging lytic cell death and inflammation therapy
Jinze Shen, Ruixiu Chen, Shiwei Duan
Abstract
NINJ1, a critical transmembrane protein in inflammation, governs diverse biological processes. Recent breakthroughs revealed NINJ1's structural basis for plasma membrane rupture, which is directly linked to lytic cell death. This discussion explores NINJ1's functions, focusing on its pivotal role in lytic cell death regulation and the latest advancements in targeted therapeutic interventions.
Topics & Concepts
Lytic cycleInflammationProgrammed cell deathBridging (networking)Transmembrane proteinCell biologyMedicineBiologyImmunologyApoptosisReceptorComputer scienceVirusBiochemistryComputer networkPhagocytosis and Immune RegulationInflammasome and immune disordersNeutrophil, Myeloperoxidase and Oxidative Mechanisms